nootropics-for-dopamine-repair

Nootropics to Repair Dopamine Receptors

When people refer to “enhancing dopamine,” it usually refers to the repairing or up-regulation of the receptors involved in the dopamine reward pathway. Here, we investigate Nootropics to Repair Dopamine Receptors naturally and easily.

Dopamine and Its Role in Addiction

Dopamine is called the “addiction molecule”. The purpose of dopamine evolution has been to motivate us to increase our survival and genetic potential. Basically, it’s the thing that drives you to pursue potential rewards. Studies show that motivated people have higher levels of dopamine, whereas low levels of dopamine are associated with a lack of motivation and joy [study]. In this blog, we go over similar concepts mentioned in my article Best Nootropics For Motivation.

As a simplification of a very complex process, dopamine activities (gaming, pornography, fast food, etc.) desensitize and down-regulate dopamine receptors – resulting in a lessened capacity to use dopamine.

This is especially true for more “hardcore” drugs like cocaine and is the reason why higher doses are needed to achieve the same effect (even caffeine). Simply put, D2 receptors display a loss of sensitivity to the neurochemical dopamine, leaving you with a higher tolerance. Moreover, these low levels of dopamine have been shown to be correlated with typically addictive practices, essentially making the subject pursue that dopamine as “high.” [study]. So, if you are seeing this article you may have been one to over-stimulate your dopamine system and overtime have hindered the receptibility of your dopamine receptors.  

Can Nootropics Help to Repair Dopamine Receptor Density?

Yes, science supports the notion of Nootropics to Repair Dopamine Receptors and has produced clinical evidence showing just that. Although addictive behaviors and drugs may increase dopamine resistance, it should be noted that some people naturally have low numbers of dopamine D2 receptors at birth [study]. Furthermore, studies show a genetic link between the specific dopamine D2 receptor gene (DRD2) and susceptibility to the development of alcohol dependence [study]. Based on this study, they found that people with this particular genetic polymorphism were more prone to suffer from dysfunction of the midbrain reward system, creating a state of low dopaminergic activity leading to symptoms of addiction, compulsion, and behavioral urges.  In later studies, one-third of the American population was observed to be carriers of this gene – displaying an average reduction of 30-40% in dopamine D2 receptors. Nootropic Supplements to Repair Dopamine Receptors For the above activities, the dependence model seems to be related to substance use. In other words, behavioral and chemical addiction cause many of the same processes and changes in brain chemistry.  Some scientists even suggest that the dopaminergic pathway is more influential than the opioid system. That is the desire for the behavior/drug can be many times more powerful than the joy obtained from the behavior/drug itself. Continued execution of these addictive behaviors further exacerbates their signals and desires, partially damaging the prefrontal cortex and impairing impulse restraint. In this way, dopamine enhancing activities like sugar, masturbation, etc. become easier and easier to say “yes” to. I think modern society is becoming more and more inclined for these dopamine surging effects. And its clear to see that much of our everyday activities have been designed to be addictive; fast food, Facebook/SM, gaming, TV, high-speed web surfing, etc. Many recent studies have shown that these factors directly influence life satisfaction. Moreover, a strong correlation between these activities and the increase in the diagnosis of anxiety, depression, ADD, and ADHD in all ages have been confirmed [study]. For me it seems obvious – the rate of technological advancements is far exceeding the progression of our monkey brain. Fortunately, with a growing understanding of these neuroscientific concepts, people are becoming more aware and choose to avoid frequent use of these activities – leading to the “restoration” of long-term dopamine-abused receptors. This can be recognized through the emergence of groups such as “No Fap” – where thousands of men (and women) are vowing to quit pornography, masturbation, and orgasm in order to restore their genetically available levels of dopamine receptibility. Similar support groups can even be observed for gaming, gambling, smoking, and many more, all of which are recognizing dopamine key part in these activities. This has similarly resulted in these groups partaking in what’s known as a “dopamine fast” avoiding; mobile phones, televisions, food (basically anything pleasurable) for a 24 hour period. This article study explores the techniques, methods, and nutrition of how to naturally repair dopamine receptors and how to stimulate the process. That being said, there is no magical resolution and the most essential part of the restorative process is eliminating dopamine increasing behavior.  

What Are The Best Nootropics to Repair Dopamine Receptors?

 

#3 Uridine

nootropics for dopamine recovery There is evidence that uridine can regulate dopamine levels through the up-regulation of striatal D2 receptors [study]. User reports state that it can reduce the symptoms of depression and bipolar disorder while improving people’s perceived level of well-being. Furthermore, uridine has been shown to help those overcoming cocaine addiction revealing a increased recovery rate . Many studies examining the effects dopamine desensitization have found that uridine supplementation can have a positive impact at reducing dopamine desensitization, two studies of which concluded;
‘This study reveals evidence that chronic uridine may alter drug-induced dopaminergic activity without exerting negative effects. ‘
‘In conclusion, these data suggest that the therapeutic effects of uridine on the dopaminergic system possibly through its agonistic nature on GABAA receptors.’

Benefits and Uses of Triacetyluridine 

  • Promote a sense of well-being
  • May help promote cognitive well-being
  • May help promote healthy stress levels
  • May help increase motivation

Triacetyluridine Dosage

Dietary supplementation of 25mg of Triacetyluridine daily.  

Best Nootropics to Repair Dopamine Receptors 

#2 CDP-Choline (Citicoline)

 

nootropics-for-dopamine-repair

The brain needs a whole lot of nutrition when performing mental tasks. Citocholine provides a bioactive source of fuel for such events. In layman’s terms, it is the chemical that allows you to stay focused throughout the day.
Choline is a naturally occurring precursor to acetylcholine and is a component of normal brain function. CDP Choline (aka Citicoline) is used as a highly-bioavailable form of choline and can be purchased at nutrition pharmacies. It is also often used for its ability to prevent age-related memory decline. Citocholine has been clinically tested to show signs that support attention, memory, and dopamine receptor density.  

Studies & Evidence of Dopamine Receptor Repair

Mice given 100 mg/kg CDP choline daily for 7 months were observed to experience D2 dopamine receptor density increase by 11% [study]. Human subjects treated with 500 mg/kg per day, D2 receptors increased by 18%[study].  

Citicoline Benefits

Citicoline supplementation may include:

  • Improved memory
  • Enhanced learning capacity
  • Increased focus and attention
  • Faster recall speed
  • Combat mental fatigue

Dosage 

Citicoline 2x250mg daily as part of a normal diet

 

Natural Sources

Natural sources of choline have vastly different capacities to penetrate the blood-brain barrier. Nevertheless, some natural sources contain fair amounts of this brain-boosting compound.
  • Egg yolk
  • Butter
  • Nuts (pistachios, cashews)
  • Pumpkin seeds

Possible Side Effects 

The possible side effects of too much choline are tension headaches. This occurs in a small percentage of the population and these users are suggested to source choline through dietary measures only.  

#1 Best Nootropics to Repair Dopamine Receptors 

 

ALCAR (Acetyl-L-Carnitine)

dopamine D2 receptor upregulation When it comes to Nootropics to Repair Dopamine Receptors look no further than acetyl L-carnitine. Acetyl L-carnitine, also known as ALCAR, is the acetylated form of L-carnitine, that is it is made after a chemical reaction has been performed, adding an acetyl functional group to L-carnitine. L-carnitine is an amino acid naturally occurring in the diet and often supplemented before working out. Acetyl L-carnitine is better absorbed than standard L-carnitine.  

Studies & Evidence of Dopamine Receptor Repair

Here are some recent findings that examined the effects of Acetyl-l-carnitine;  
Via upregulating dopamine D1 receptors and attenuating microglial activation, acetyl-L-Carnitine  was shown to prevent neuronal loss and improve memory in Parkinsonian rodents L-Carnitine significantly reduced impulsive behavior in dopamine impaired ADHD rats

Reversal of  memory loss symptoms in old rats after feeding acetyl-L-carnitine

Acetyl-l-carnitine improves spatial learning in senescent rat subjects  

Benefits

The natural production of L-carnitine in the body has been seen to decrease over time, resulting in the impairment of mitochondrial function. Acetyl-L-carnitine supplements can help to reverse this process and boost energy in fatigued individuals. Energy is one of the most well-reported benefits of many acetyl L-carnitine, and users report that can additionally improve cognitive performance whilst reducing physical fatigue.  

Mechanism

Acetyl L-Carnitine is known to promote mental energy and is recognized as a natural intelligence enhancing supplement. Its benefits are derived from the increased transport of fatty acids into the mitochondria of the cell enabling brain cells with an increased energy supply. Acetyl-L-carnitine has also been found to have neuroprotective effects in the brain, resulting in improved tissue health and brain cognitive function.  

Dosage 

1x 500mg Acetyl L-Carnitine HCL capsule daily.  

Nootropics to Repair Dopamine Receptors – Final Thoughts

Nootropics to repair dopamine receptors are being used by more and more people due to their strong neurodegenerative and neuroprotective characteristics. This article uncovers and examines the latest available research concerning these unique brain-altering compounds and their effect on the recovery of dopamine D1 and D2 receptors. The research in this field appears very promising and the medical interventions for such compounds are being clinically trialed for their ability to assist recovery in certain drug and behavior addictions, as well as age-related cognitive and memory decline. The most effective substances shown to produce this growth of receptor density are considered to be acetyl-l-carnitine, citicholine, and uridine.  

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