Nootropics for better sleep

Nootropics for Sleep | Ultimate Guide

In this article, we uncover the efficacy of Nootropics for Sleep to understand whether they are a good or bad option.  I will be discussing the pros and cons of every supplement mentioned. As well as the evidence behind their effects. If you have any questions, please leave them in the comments section below.

How many nights have you spent staring at the ceiling? Attempting to count sheep and distract your mind from the pressuring thought of having to be up early tomorrow. The sad reality is that Western civilization is plagued by insomnia.

Take Japan for example. After one train ride, you quickly realize how they may experience an easier time sleeping. This is a trait of many other Asian countries as well and suggests that our sleeping problems may arise from the construct of our everyday life.

When considering an option for your sleeping disturbances, you should always address your everyday behaviors before attempting any supplements, particularly nootropics for sleep.

Let’s first discuss common hormonal disturbances that may hinder relaxation and sleep. 

 

nootropics for ADHD

Mechanism Behind Ideal Nootropics for Sleep? 

Often the body is compared to a seesaw. Fight or flight is also a common term used. No matter what you call it, the stress and relaxation, the yin and yang, is a key part of being a balanced human. 

The problem is many of us lose this balance. The question then becomes how can we regain it.

To do this let’s discuss 

The Biochemistry of Stress

Cortisol is a steroid hormone released from the adrenal glands. The release is in response to events that are stressful or are perceived as stressful.

Without going into any further detail it is clear to already note that if one changes how they perceive an event, they can ultimately change the physiological outcome. Nevertheless, the outcome of continuously experiencing threats will affect your life and sleep in detrimental ways. 

Nootropics for Sleep and Stress

One of the more common nootropics for sleep renowned for its affects on cortisol management for is…

#1 Ashwagandha (Withania somnifera)

Nootropics for sleep ashwaghanda

As we discussed, cortisol travels in response to an event (real or thought) and will begin to dilate blood vessels in an attempt to prime the body for action or escape. The physiological procedure for which this is performed can be understood simply as a “lock and key” mechanism. 

The signal (cortisol) fits into the target cells (digestive organs, blood vessels, etc.), initiating the beginning of the response action.

Ashwagandha is what is known as an adaptogen, which is defined as a supplement that acts to increase the body’s tolerance to this cortisol response.

This has been found to have significant effects on lowering perceived levels of “stress”.

Ashwagandha – Evidence for Stress Relief and Sleep

Ashwagandha has prevailed as a herbal remedy to treat the effects of cortisol imbalance in the body. Researchers have experimented on these effects and reveal some of the following findings:

 

Dosage & safety 

Ashwagandha has experienced rigorous testing and is deemed of low toxicity to humans. 

Those wishing to try ashwagandha should first start at a lower dosage of around 1000 mg per day. This has been shown to positively impact stress in daily life. 

However, dosages can be slowly elevated to around 2000 mg per day – it should be noted that it takes several weeks ashwagandha full effect to take place.

After observing this it is very apparent that ashwagandha can be of benefit to not only those with higher stress levels but interestingly,  also those with lower levels of cortisol – appearing to additionally act as a remedy for those struggling with cortisol induced energy difficulties.

An interesting point of ashwagandha is that if taken with black pepper, the effects become significantly stronger as the active ingredients increase in bioavailability. Because of this, some supplements now include Black Pepper extract as an ingredient.

Ashwagandha is not the only adaptogen available. Similar benefits and more have been found in our next herb.

 

Check out our: Nootropics for Motivation guide

#2 Rhodiola Rosea

Nootropics for sleep rhodiola

Is a plant that grows in the wild arctic regions of Europe and Asia. This one has been found to have significant effects upon the response to stress also.It has additionally been recognized for its capacity to increase feelings of well being and relieve depression. 

Studies on Rhodiola Rosea 

 

  • 576 mg found to positively impact  fatigue levels and attention, compared to the placebo [10]
  • 400 mg daily, eight weeks resulted in significant improvements in stress symptoms, fatigue, life quality, temperament, and focus [11
  • 200 mg of Rhodiola extract significantly improved stress in daily situations after three days. After four weeks, all subjects reported significant improvement [12]
  • 400 mg daily found to significantly improvement stress and mood following one week [13]

Best Nootropics to Increase Melatonin

So I get it right, you want to be mentally sharp but still want to be able to sleep at night? That is why many are hacking their physiology with natural supplements. The following nootropics that enhance the construction of melatonin may be your solution.

To understand the ideal nootropic for sleep that may increase melatonin, we should first understand the mechanism behind how melatonin is formed in the body.

What The Body Needs to Make Melatonin…

To create melatonin, the body needs serotonin. However, if you’re someone who suffers from stress you may also be suffering from low levels of serotonin.

Serotonin receptors are found throughout the whole body. The effect of serotonin activation will induce different actions depending on the location. Take the prefrontal cortex receptors for example. They relate to mental processing and awareness, whereas hippocampal receptors assist with learning and memory.

Scientists are not exactly sure about the mechanism, but findings suggest low serotonin to be associated with decreased feelings of happiness and may additionally express itself as symptoms of OCD.

So when it comes to increasing melatonin production, it makes sense to first attempt to regain normal levels of serotonin.

So the question becomes which Nootropics to can be used to increase serotonin?

To indirectly increase levels of melatonin, we can use nootropics that raise serotonin levels to our advantage.

Nootropics for Serotonin and Sleep l-tryptophan 

  • Tryptophan supplementation significantly increases melatonin production reducing time to sleep [56].
  • L-tryptophan supplementation improved average total sleep amongst healthy individuals. Drowsiness was a common immediate side-effect [7].
  • Tryptophan supplementation significantly improved sleep for manic patient subjects. Total sleep after L-tryptophan increased dramatically [8].
  • L-tryptophan (250 mg) increased stage 4 deep sleep [9].

Through its role as a precursor to serotonin and therefore melatonin,  tryptophan is considered as an appropriate nootropic for sleep.

It can be used to increase serotonin and melatonin which has been shown to increase sleep quality and reduce time to fall asleep.

 

Check out our guide: Top Nootropics For Social Anxiety

Additional ways to increase melatonin

 Nootropics for sleep light therapy

Light therapy

Like therapy consists of regulating your body around sunrise and sunset.

Those looking to restore circadian rhythm with this method should avoid LCD phone, laptop, and TV screens for at least 3 hours before bed. This decrease in blue light radiation has been shown to increase melatonin’s natural release from the pineal gland.

The Bottom Line 

Trying to achieve peak mental performance without disturbing sleep is challenging. However, there is increasing evidence to suggest that improved cognition does not have to be a result of just stimulant type medications that many all too often rely on. 

Supplementing with compounds known to increase key neurotransmitters to sleep and relaxation is the crux of being mentally sharp and calm. As we discussed, nootropics that are useful for sleep are the ones that promote the production and use of neurotransmitters serotonin and GABA. Reducing the effects of cortisol in the body similarly can relieve the tension that prevents many from sleep. Ideal Nootropics for Sleep may include; Rhodiola Rosea, Ashwagandha, phenibut, and L-tryptophan.

What do you think? Do these compounds have the potential to replace harsh sleeping medication? Let me know in the comments down below   ⬇⬇

References

[1] Panossian A, Wikman G (2010). “Rosenroot (Roseroot): Traditional Use, Chemical Composition, Pharmacology, and Clinical Efficacy”. Phytomedicine. 17 (5–6): 481–493. DOI:10.1016/j.phymed.2010.02.002. PMID 20378318.

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/

[3] Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62. DOI: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577.

[4] Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine. 2019;98:37(e17186)

[5] Szczepanik M. Melatonin and its influence on the immune system. J Physiol Pharmacol. 2007 Dec;58 Suppl 6:115-24. PMID: 1DOI2405.

[7] Wyatt RJ, Engelman K, Kupfer DJ, Fram DH, Sjoerdsma A, Snyder F. Effects of L-tryptophan (a natural sedative) on human sleep. Lancet. 1970 Oct 24;2(7678):842-6. DOI: 10.1016/s0140-6736(70)92015-5. PMID: 4097755.

[8] Murphy DL, Baker M, Goodwin FK, Miller H, Kotin J, Bunney WE Jr. L-tryptophan in affective disorders: indoleamine changes and differential clinical effects. Psychopharmacologia. 1974 Jan DOI(1):11-20. DOI 10.1007/BF00421216. PMID: 4593517

[9] Hartmann E, Spinweber CL. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. J Nerv Ment Dis. 1979 Aug;167(8):497-9. PMID: 469515

[10] Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12. doi: 10.1055/s-0028-1088346. Epub 2008 Nov 18. PMID: 19016404.

[11] Llekomtseva Y, Zhukova I, Wacker A. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial. Complement Med Res. 2017;24(1):46-52. doi: 10.1159/000457918. Epub 2017 Feb 17. PMID: 28219059.pp

[12Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms–results of an open-label study. Phytother Res. 2012 Aug;26(8):1220-5. doi: 10.1002/ptr.3712

 

Nootropics for Studying

Nootropics for Studying | 3 Scientifically Proven

So, you’ve heard about Nootropics for Studying but unsure where to start… All assignments have been completed. You were on time and paid close attention to every class. Now you’re face-to-face with the exam. This is where all your hard work comes together to take the mark that you truly deserve.  The only problem is that every time you try to study, you struggle to maintain ample motivation and the attention to fully absorb the information you need. It only becomes worse when you begin to stress about how little progress you’re making… Trust me, I’ve been there and know how difficult it can be. This is where nootropics for studying may help, and it’s a solution more and more are turning to. So today I decided to do some research. 

Nootropics For Motivation - Rhodiola

You’ve probably heard about the growing use of Nootropics for Studying. And it’s true, they are receiving more attention than ever before. And if you look around the internet, you’ll be sure to hear many stories. Their main use is believed to be their capacity to enhance aspects of learning, concentration, and memory. After reading the latest scientific articles around these compounds, their popularity came as no surprise  So, this research goes all to all those late-night stimulant-seeking-studiers. Now caffeine (or even prescription meds like Adderall) are not your only options. These days there are many options available and free of side effects of traditional stimulants. Let’s first dive into the biochemistry behind what makes the best nootropics for studying. 

What Brains Need to Study

To focus, our brains utilize neurotransmitters. Our attention span and concentration relies on the neurochemicals; acetylcholine, dopamine, and norepinephrine.
  • Acetylcholine – used by the brain in signal processing within the sensory regions, acetylcholine is a neurotransmitter integral to attention and focus. It is also recognized as a chemical that enables us to avoid distractions.
  • Norepinephrine – closely follows the processing of dopamine and is a key component of wakefulness, alertness, cognitive capacity, and thought-processing speed.
  • Dopamine – accountable for conducting the reward-response system in the brain. In short, its the chemical released after a reward that works to reinforce the behavior. Not only is it stimulated following modern-day rewards like social media, but it also rises in response to problem-solving and learning, and is a key factor in motivation.

See our guide to the 5 Best Nootropics for Motivation here

  Now that we have discussed the biological process’s behind what an effective nootropic may do, let’s dive straight into the top scientifically proven Nootropics for Studying.  

Best Nootropics for Studying #3

Our best approach toward finding the best nootropics for studying relies on the effective increase of these aforementioned neurotransmitters;  acetylcholine, dopamine, and norepinephrine. After digging around through many clinical scientific papers I have found evidence for the most effective nootropics, shown to elevate these neurotransmitters with little risk of side effects.

Bacopa monnieri

Nootropics for study Bacopa Bacopa monnieri is a plant originating from southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America. It is sold throughout many supplement stores commonly under the name “Bacopa”, or “Brahmi”. The plant is an integral part of traditional Ayurvedic medicine, and has been used for thousands of years for its ability to improve;
  • Memory loss,
  • Anxiety
  • Poor cognition
  • Loss of concentration 
  • Inflammatory disorders like arthritis. 
Scientists have researched the physiological mechanisms behind the ayurvedic plant to test these claims. A great deal of very exciting evidence has been found. All of which may now be attributed to the inhibitory action it has on inflammatory pathways in the brain. One 2016 study titled, “The Ayurvedic plant Bacopa Monnieri inhibits inflammatory pathways in the brain [1]” concluded the following;
Our results suggest that bacopa can significantly ameliorate the M1 microglial response by reducing the release of TNF-α and IL-6, leading to a decrease in neuroinflammation.”
The researchers continue to discuss the use of this data in terms of its effect on systemic inflammation and hypothesize that the mental health benefits of the plant may be a product of its anti-inflammatory effect on the CNS.  These findings have been supported in both animal and human models both that show robust evidence [2] for the plant’s ability to improve memory, attention, and the processing of visual information. As well as the numerous studies [3] revealing bacopa’s effectiveness to treat anxiety, the plant has similarly been found to alleviate symptoms of restlessness and impulsivity in ADHD subjects [4].

Studies on Bacopa monnieri supplementation for Studying

The nootropic properties of bacopa are well-founded and numerous studies conclude significant cognitive boosting effects following ingestion. Although best results are observed with consistent use. One fine example of this effect is shown in this double-blind placebo-control study [6] testing the effects of 300 mg of a 45% bacosides extract. The results concluded that after three months of supplementation there were significant improvements in; spatial memory, memory accuracy, and ability to process visual information.  The scientists discuss the mechanisms behind these effects and attribute the benefits to inhibition of acetylcholinesterase, allowing the brain to utilize more choline. As we mentioned earlier, this is a key component to improving one’s focus while studying.

Dosage for Nootropic/studying Purposes

For a supplement containing 45% bacosides, a recommended dosage of 200 – 450 mg per day is usually given, whereas a 20% bacoside formula should be dosed up to 700mg per day. Absorption of this supplement will be aided by the ingestion of fat, therefore users are advised to take the supplement with a meal, fish oil supplement, or some coconut oil.

Bacopa monnieri Safety

Bacopa monnieri is usually considered as a safe and natural approach to the treatment of many mental health disorders, however, some people may notice nausea, stomach pains, and diarrhea following supplementation.

Pregnant women and those taking any medications, particularly pain relievers/ anti-depressants are advised to avoid this herb.

 

Nootropics for Studying #2

CDP-Choline 

CDP-Choline is a molecule commonly found in the body as a component of cell membranes. Its structure consists of a uridine group and a choline backbone. This essentially provides a “two birds one stone” effect as the body can break down and utilize each of these molecules separately. Not only can CDP-choline provide an available form of choline (which again is necessary for thought processing), uridine has also been shown to be one of the best supplements to improve one’s motivation. This is visible in studies reflecting uridines’ potential to upregulate striatal D2 receptors. In this study, researchers suggest that this upregulation could in turn provide the alleviation of urges, particularly those related to drug-addicted. This ties in very strongly with having an effective study session as many aspects of our everyday modern-day lifestyle has been shown to cause addiction-like brain changes. I have discussed these concepts in detail and for those looking to recover dopamine receptors, I encourage you to check out my research on “Nootropics to Repair Dopamine Receptors”.

Studies on CDP-Choline supplementation for Studying

  • CDP-choline supplementation shows significant improvement in cognition amongst cardiac ischemic subjects. Mechanism of action believed to be of vascular origin [6]
  • CDP – choline supplementation shows cognitive improvements amongst young, non-demented subjects [7]
  • Citicoline raises verbal memory in elderly subjects [8]
  • CDP-Choline magnifies the release of norepinephrinedopamineserotonin, and acetylcholine in the brain. [9] [10]
  • CDP-Choline improves cognition and impulsivity in marijuana abusing subjects [11]

CDP-Choline vs. Alpha-GPC for Cognition

CDP-choline and alpha-GPC are both comprised of choline however, the body metabolizes and uses them in various manners. Normally CDP-choline releases choline and cytidine (which will turn into uridine), this then gives the body an option; to create phosphatidylcholine, which the brain utilizes to construct acetylcholine or to build cell membranes. This is slightly different from Alpha-GPC as it often prefers the pathway for the production of acetylcholine [12].

CDP-Choline (Citicoline) Dosage for Study

The following amounts yielded beneficial results in clinical trials: Cognition and memory improvements: 250 – 1,000 mg/day  Age-related cognitive decline: 1 000 – 2,000 mg/day Drug addiction, depression, and stroke recovery – 2,000 – 2,500 mg daily    Check out more: Best Nootropics for Social Anxiety

Nootropics for Studying #1 

Phenylpiracetam

More and more who are seeking increased potency when attacking their study session turn to the effects of phenylpiracetam. It is a molecule produced by the addition of a “phenyl” group to piracetam which in effect, creates a greater bioavailability for the compound as it is granted easier access through the blood-brain barrier. Albeit limited, there are promising findings around this compound and scientists are optimistic about the relatively novel compound (1983). This means that this nootropic is not as extensively studied when compared to our aforementioned supplements, but despite this, phenylpiracetam continues to grow in popularity as many swear by its superb cognitive boosting and anxiety-relieving benefits. Although a lot of questions still remain about phenylpiracetam, scientists are aware of its ability to increase the blood supply to the brain, raising oxygen availability. Many scientists are now asserting that the compound also has the potential to increase the density of receptors of dopamine, serotonin, and GABAa  [20]. Needless to say, this supplement does sound very promising however no long-term studies evaluate the long-term consequences of supplementing this compound. Thus this nootropic should be not be approached lightly and user discretion is very necessary.

Studies on Effects of Phenylpiracetam

Alleviation of symptoms of anxiety and depression

  • 1 Month of supplementation found to significantly Reduce Anxiety and Depression in 99 Brain-Damaged Patients [13]
  • 35 patients with Anxiety and Depressive Disorders, treated for 12 weeks found to have a significant Reduction in Anxiety [14]
  • Found to significantly reduce behaviors of Anxiety in mice subjects when placed into an unknown environment [15].

Improvements in Cognition

  • Significantly increased memory quiz scores of 55 patients with energy-related (asthenia) disorder as well as chronic fatigue syndrome (n=59)  [16] 
  • Significantly increased aspects of memory function in mice [17]
  • Increased nicotinic acetylcholine and NMDA receptor density – shown to beneficial in aspects of learning and memory [18, 19]
So, scientists are optimistic about the evidence for this nootropic, hoping that one day it may not only provide patients with relief from anxiety disorders but also improve learning and memory issues. Those reading should not take this as a reason to eagerly start supplementing with phenylpiracetam. Further research clearly needs to be performed to learn the full extent of this compound. As of now, researchers believe that it may be useful for addressing receptor irregularities in some unhealthy subjects.

Possible Adverse Reactions

As with any drug, phenylpiracetam can cause some unwanted effects. Some of which may include; Headaches, sleep disturbances, and irritability As most of this may reside from the increased expenditure of acetylcholine, to decrease your chance of experiencing side-effects, users are advised to supplement with choline. The studies that have been performed on phenylpiracetam suggest that it the compound of very low toxicity. This nootropic tends to increase endurance and tolerance to cold weather. Because of this, it is banned by the World Anti-Doping Agency for in-competition use. If you decide to “test” this relatively new compound, ensure awareness of adverse side-effects. It is strongly advised to consult your doctor prior to use   

Final thoughts before taking Nootropics for Studying

Research continues to unveil potential uses for certain brain-altering compounds, suggesting improvement across various aspects of cognition and function. When considering study enhancing supplements, one should consider compounds that support the integral reactions observed in attention an focus; Dopamine, Acetylcholine, and Norepinephrine. Research suggests that supplementation of Bacopa, CDP-choline (citicoline), and phenylpiracetam could all alter these neurochemical reactions leading to improvements of cognition. Risk comes with taking any supplement and research behind nootropics still has further progress to be made. That being said, many are now beginning to recognize nootropics as a way to boost cognition in the mentally deteriorated. It similarly provides a debatably safer option that well-known stimulant drugs e.g. Adderall. What do you think about the growing use of Nootropics for Studying?🤔  Is this something parents and uneducated users should be concerned about? 🛑 Let me know in the comments down below ⬇⬇      

References

  [1] Nemetchek MD, Stierle AA, Stierle DB, Lurie DI. The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. J Ethnopharmacol. 2017;197:92-100. doi:10.1016/j.jep.2016.07.073
[2] Peth-Nui T, Wattanathorn J, Muchimapura S, Tong-Un T, Piyavhatkul N, Rangseekajee P, Ingkaninan K, Vittaya-Areekul S. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. Evid Based Complement Alternat Med. 2012;2012:606424. doi: 10.1155/2012/606424. Epub 2012 Dec 18. PMID: 23320031; PMCID: PMC3537209.
.
[3] Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001 Aug;156(4):481-4. doi: 10.1007/s002130100815. Erratum in: Psychopharmacology (Berl). 2015 Jul;232(13):2427. Dosage error in article text. PMID: 11498727
[4] Dave UP, Dingankar SR, Saxena VS, Joseph JA, Bethapudi B, Agarwal A, Kudiganti V. An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children. Adv Mind Body Med. 2014 Spring;28(2):10-5. PMID: 24682000.
[5] Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008 Dec;22(12):1629-34. doi: 10.1002/ptr.2537. PMID: 18683852.
[6] Tan H, Wasiak J, Rosenfeld JV, O’Donohoe TJ, Gruen RL. Citicoline (CDP-choline) for traumatic brain injury. Cochrane Database of Systematic Reviews 2014, Issue 8. Art. No.: CD011217. DOI: 10.1002/14651858.CD011217 [7] Poly C, Massaro JM, Seshadri S, Wolf PA, Cho E, Krall E, Jacques PF, Au R. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr. 2011 Dec;94(6):1584-91. doi: 10.3945/ajcn.110.008938. Epub 2011 Nov 9. PMID: 22071706; PMCID: PMC3252552. [8] Spiers PA, Myers D, Hochanadel GS, Lieberman HR, Wurtman RJ. Citicoline improves verbal memory in aging. Arch Neurol. 1996 May;53(5):441-8. doi: 10.1001/archneur.1996.00550050071026. Erratum in: Arch Neurol 1996 Oct;53(10):964. PMID: 8624220. [9] Petkov VD, Stancheva SL, Tocuschieva L, Petkov VV. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). Gen Pharmacol. 1990;21(1):71-5. doi: 10.1016/0306-3623(90)90598-g. PMID: 2105261. [10] Agut J, Coviella IL, Wurtman RJ. Cytidine(5′)diphosphocholine enhances the ability of haloperidol to increase dopamine metabolites in the striatum of the rat and to diminish stereotyped behavior induced by apomorphine. Neuropharmacology. 1984 Dec;23(12A):1403-6. doi: 10.1016/0028-3908(84)90080-7. PMID: 6543245. [11] Blusztajn JK, Liscovitch M, Mauron C, Richardson UI, Wurtman RJ. Phosphatidylcholine as a precursor of choline for acetylcholine synthesis. J Neural Transm Suppl. 1987;24:247-59. PMID: 3316498. [12] Crean RD, Crane NA, Mason BJ. An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions. J Addict Med. 2011;5(1):1-8. doi:10.1097/ADM.0b013e31820c23fa [13] Savchenko AIu, Zakharova NS, Stepanov IN. [The phenotropil treatment of the consequences of brain organic lesions]. Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(12):22-6. Russian. PMID: 16447562. [14]  Medvedev VE, Frolova VI, Epifanov AV. [New possibilities of pharmacotherapy in cardiovascular patients with mental disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(9):30-7. Russian. PMID: 25403298. [15] Vasil’eva EV, Salimov RM, Kovalev GI. [Effects of nootropic drugs on behavior of BALB/c and C57BL/6 mice in the exploratory cross-maze test]. Eksperimental’naia i Klinicheskaia Farmakologiia. 2012 ;75(7):3-7. [16] Kalinskiĭ PP, Nazarov VV. [Use of phenotropil in the treatment of asthenic syndrome and autonomic disturbances in the acute period of mild cranial brain trauma]. Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(2):61-3. Russian. PMID: 18689001. [17] Zvejniece L, Svalbe B, Veinberg G, Grinberga S, Vorona M, Kalvinsh I, Dambrova M. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):407-12. doi: 10.1111/j.1742-7843.2011.00742.x. Epub 2011 Jul 20. PMID: 21689376. [18] Zvejniece L, Svalbe B, Veinberg G, Grinberga S, Vorona M, Kalvinsh I, Dambrova M. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):407-12. doi: 10.1111/j.1742-7843.2011.00742.x. Epub 2011 Jul 20. PMID: 21689376. [19]  Firstova, Y.Y., Abaimov, D.A., Kapitsa, I.G. et al. The effects of scopolamine and the nootropic drug phenotropil on rat brain neurotransmitter receptors during testing of the conditioned passive avoidance task. Neurochem. J. 5, 115–125 (2011). https://doi.org/10.1134/S1819712411020048
Nootropics for ADHD

Nootropic Supplements for ADHD

In this article, we investigate various Nootropic Supplements for ADHD. We assess the neurological foundation of ADHD and hypothesize the use of certain brain-altering compounds to manage the disorder.

How Much Can Science Tell Us About ADHD?

ADHD or attention-deficit/hyperactivity disorder is one of the most prevalent neurobehavioral disorders in our society. But don’t be deceived, it is by no means a single or simple disorder. There are several theories regarding ADHD. The most commonly accepted is the low arousal theory which suggests that ADHD/ADD patients have lower tonic dopamine levels in the brain. In short, this results in the patient displaying problematic symptoms related to attention and hyperactivity. Other informal research methods suggest that there can be up to 7 main types of ADD believed to affect distinct areas of the brain — the prefrontal cortex and cerebellum primarily. Although the cause of ADHD still remains of mystery, scientists seem to agree that the symptoms result from an imbalance in the neurochemicals; dopamine, serotonin, and GABA.  

Symptoms of ADHD

Before discussing the effectiveness of certain Nootropic Supplements for ADHD, let’s first take a look at the acknowledged symptoms of the common ADHD patient. Note ADD is characterized by the same core symptoms of ADHD (excluding hyperactivity). It is equally as common. Visual signs of ADHD
  • Excessive daydreaming
  • Forgetful or easily loses things
  • Difficulty staying still
  • Talkativeness
  • Careless mistakes or take unnecessary risks
  • Decreased ability to resist urges
  • Lack of social skills
  • Impulsivity
You’d probably expect there to be some well-known neurological dysfunction in the brains of ADHD suffers, right? However, scientists have struggled to identify the exact processes involved in this disorder and like other mental disorders, (autism, etc) the disorder is believed to occur on a spectrum.  

Why Nootropic Supplements for ADHD?

Nootropic Supplements for ADHD amino Acids

As we medical researchers still do not fully understand the mechanism behind ADHD/ADD, it comes as a surprise that extremely strong and addictive medications are so often prescribed. Don’t get me wrong, these drugs can improve the symptoms of ADHD, but the host of unfavorable side effects should not be neglected. Some of these stimulants’ side effects include; headaches, sleep problems, loss of appetite, tolerance, and dependency.  

Why Are Stimulants Given to ADHD patients?

Two major categories of clinical treatments are methylphenidate and amphetamines – both potent stimulants affecting of tonic dopamine levels. For users without ADHD, these drugs will increase symptoms of hyperactivity whereas in ADHD patients, they result in a decreased urge to seek tonic dopamine in the environment – theoretically decreasing hyperactivity. Some common of these dopamine stimulating medications include Ritalin, Adderall, Vyvanse, Concerta So you might be wondering… Can’t nootropics increase dopamine in the brain too? Correct, nootropic supplements like Rhodiola Rosea, green tea extract, Ginseng, and amino acids like L-tyrosine and 5-HTP are all shown to increase dopamine activity in the brain. These remedies are now receiving the attention of clinical Studies aiming to determine their effectiveness in relieving ADHD symptoms. This is supported anecdotally across internet forums where ADHD patients are reporting improved symptoms following nootropic supplementation.  

Are Nootropic Supplements for ADHD Effective?

As scientists still define the effectiveness behind common nootropics I believe it may be in our best interest to seek anecdotal n=1 reports to answer this question. One Reddit ADHD suffer mentions the following;
“I’ve been struggling with debilitating ADHD and anxiety since my early teenage years. I tried lots of SSRI, SNRI, Wellbutrin, Ritalin, benzos with little help. I even ended up in the hospital from benzo withdrawals and had two seizures. My anxiety levels were overwhelming to the point I could not stand out of a bed for half a year… Anxiety actually came out from ADHD symptoms that I couldn’t manage and really messed my life in the long term (financially, relationship-wise…etc). But in the past year, I have been experimenting with nootropics and think I have found a sweet spot for anxiety-ADHD related problems. So after my years of struggling and trying different psych meds and two months of nootropics I can say I got my glasses and lasers back on the track!
There are many comments similar to the above that have sparked the global interest of many medical scientists. This then grants the question, “which Nootropic Supplements for ADHD work best?”   Check out our ultimate guide on how to boost dopamine sensitivity today using nootropics; here 

Nootropics for ADHD

 

Phenibut

Note the full effects of phenibut are still not well understood and has been observed to cause severe addiction in recreational users. Nevertheless, it is available for over-the-counter purchase in the United States.

Phenibut is a GABA psychotropic drug found to produce potent anxiolytic and intellectually stimulating effects. It originates from Russia where it is commonly prescribed for PTSD, anxiety, fatigue, insomnia, depression, and alcoholism. The pharmacological properties of the compound, include effects on GABAA, GABAB, dopaminergic, and benzodiazepine receptors,which have been compared to the effects of diazepam and piracetam [study] In the United States, phenibut is listed as a nutritional supplement. Despite this, it is commonly abused for recreational purposes. Those who regularly partake in these activities report signs of addiction and dependence and for these reasons, some countries such as the UK have prohibited the trade of Phenibut.

Results on ADHD

Nevertheless, in controlled environments, Russian scientists have experimented with the effectiveness of Phenibut in the treatment of ADHD sufferers with great success. There is research proposing that phenibut can help relieve the symptoms of inattentiveness in ADHD patients. This is best explained in one study of 50 Russian children with ADHD, where levels of cognition, self-control, persistence, attention, and memory were significantly improved after 1 month of dosing 500-700 mg of phenibut per day.    

GABA agonists have been utilized diversly for their ability to promote sleep in Japan

  Being a rather small study, one should not conclude that phenibut is effective in the treatment of ADHD symptoms. However, these are promising steps that indicate a potentially effective solution to treat ADHD without stimulants. Future studies regarding phenibut in relation to ADHD should build upon the well-founded neurostimulatory properties that the drug produces.  

Korean Ginseng

Nootropic Supplements for ADHD Korean Ginseng, (also known as Panax Ginseng,  Asian ginseng, and Chinese Ginseng), is a class of plants whose root provides a vital source of ginseng. It is a longer-living plant that grows in the mountainous regions of East Asia. The following list of proposed benefits have regarded as an integral part of Asian and traditional Chinese medicine:
  • Stimulation of the immune system
  • Increase vitality
  • Adapt to stress
  • Support heart health
  • Reverse impotence
  • Treat diabetes

Results on ADHD

Korean Ginseng, particularly Korean Red Ginseng, has been recognized for its strong potential to relieve symptoms of inattentiveness in attention-deficit patients. This is best exemplified in clinical studies, that found Korean Red Ginseng to significantly improve the attention of ADHD children. These outcomes have been proposed to offer a natural solution to more addictive stimulant medications, however, its effects on other symptoms of ADHD such as depression and anxiety have not been actively assessed and require further study. Whether Korean Ginseng can improve the symptoms of ADHD to the extent of not requiring other stronger forms of medication is not yet known. However, researchers are optimistic about the potential behind this root and its effect on the ADHD brain. Some believe that the root may pave the way to a holistic form of treatment for the disorder.  

Amino Acid Precursors; L-Tyrosine and 5-HTP

We introduced this article stating that ADHD can be recognized as an imbalance of the neurochemicals dopamine and serotonin. The body is faced with the task of constructing both of these compounds using the proteins that we obtain from our diet. This understanding has led to the hypothesis that concentrated forms of these naturally occurring amino acid molecules may assist the body’s capacity to build these aforementioned neurotransmitters – thus potentially reducing symptoms of anxiety, depression, motivation, and inattentiveness. This hypothesis has been considered fitting in this clinical study where 85 ADHD children subjects were treated with both L-tyrosine (the amino acid precursor of dopamine) and 5-HTP (the amino acid precursor of serotonin). ADHD symptoms were then measured 8 weeks following treatment via a globally recognized ADHD symptom scale. Here is what the paper concluded;
In total, 67% of participants achieved significant improvement with only amino acid precursors of serotonin and dopamine.
These are indeed very promising results. The paper also discusses that the effectiveness of most traditional stimulant treatments was not significantly higher than results achieved through the amino acid supplementation – indicating that further research should compare the effectiveness of these natural treatments vs the usual stimulatory medical interventions that result in many more negative side effects.  

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    Placebo 

    Nootropic Supplements for ADHD placebo This solution may seem far fetched. Nevertheless, researchers have noticed that 28%–40% of placebo patients can achieve significant relief of ADHD symptoms. A placebo treatment typically means that the patient is convinced that the drug they are given is effective against their unpleasant symptoms. The point of interest here is that scientists have discovered those with ADHD to be particularly susceptible to this phenomenon. As shown in this clinical study, that resulted in placebo treatments to have similar success when compared to traditional stimulant prescription medication. This effective method of treatment raises interesting questions regarding the disorder. Namely, why are ADHD subjects more susceptible to the effects of placebo? Further research should examine this topic to identify if the method could replace stronger medications that are shown to be just as effective.  

    How to Test this Method

    Utilizing this remedy at home proves difficult for many adults. However, it may provide an effective solution for parents looking to relieve their child’s symptoms of ADHD without heavy medication. This could be done by discussing the issues with the child and informing them about how the “magic pill” will help them. Parents should not use this as a definitive method of treatment and should discuss this experiment with a health care professional. Unfortunately for us adults, it is a little more challenging to implement this strategy at home, although not impossible. A possible solution for those already taking traditional medications (and looking to stop taking them) does exist. That method consists of replacing some of the medically prescribed capsules with placebo sugar capsule treatments. This method depends on the medication the patient is already receiving and it is essential to consult a health care professional before removing any medications. Overall, these findings suggest that medical professionals/researchers/psychologists should perhaps further consider this line of treatment before prescribing complex medications.  

    Nootropic Supplements For ADHD – Final Thoughts

    The neurostimulatory properties of nootropic supplements are being clinically recognized for their efficacy in fighting symptoms of ADHD. Supplements that promote the activity of serotonin, dopamine, and GABA are found to best relieve these symptoms. Although the studies discussed today have made considerable progress regarding the use of Nootropic Supplements for ADHD, it is clear to see that there is still a lot to learn about this complex disorder. Those who suffer from the disorder should take a multi-faceted approach when dealing with the illness and treat themselves from a medicinal and behavioral standpoint. Many apps, planning tools, and feedback systems have been designed to assist those with ADHD and have shown to be effective in doing so.        
    nootropics-for-dopamine-repair

    Nootropics to Repair Dopamine Receptors

    When people refer to “enhancing dopamine,” it usually refers to the repairing or up-regulation of the receptors involved in the dopamine reward pathway. Here, we investigate Nootropics to Repair Dopamine Receptors naturally and easily.

    Dopamine and Its Role in Addiction

    Dopamine is called the “addiction molecule”. The purpose of dopamine evolution has been to motivate us to increase our survival and genetic potential. Basically, it’s the thing that drives you to pursue potential rewards. Studies show that motivated people have higher levels of dopamine, whereas low levels of dopamine are associated with a lack of motivation and joy [study]. In this blog, we go over similar concepts mentioned in my article Best Nootropics For Motivation.

    As a simplification of a very complex process, dopamine activities (gaming, pornography, fast food, etc.) desensitize and down-regulate dopamine receptors – resulting in a lessened capacity to use dopamine.

    This is especially true for more “hardcore” drugs like cocaine and is the reason why higher doses are needed to achieve the same effect (even caffeine). Simply put, D2 receptors display a loss of sensitivity to the neurochemical dopamine, leaving you with a higher tolerance. Moreover, these low levels of dopamine have been shown to be correlated with typically addictive practices, essentially making the subject pursue that dopamine as “high.” [study]. So, if you are seeing this article you may have been one to over-stimulate your dopamine system and overtime have hindered the receptibility of your dopamine receptors.  

    Can Nootropics Help to Repair Dopamine Receptor Density?

    Yes, science supports the notion of Nootropics to Repair Dopamine Receptors and has produced clinical evidence showing just that. Although addictive behaviors and drugs may increase dopamine resistance, it should be noted that some people naturally have low numbers of dopamine D2 receptors at birth [study]. Furthermore, studies show a genetic link between the specific dopamine D2 receptor gene (DRD2) and susceptibility to the development of alcohol dependence [study]. Based on this study, they found that people with this particular genetic polymorphism were more prone to suffer from dysfunction of the midbrain reward system, creating a state of low dopaminergic activity leading to symptoms of addiction, compulsion, and behavioral urges.  In later studies, one-third of the American population was observed to be carriers of this gene – displaying an average reduction of 30-40% in dopamine D2 receptors. Nootropic Supplements to Repair Dopamine Receptors For the above activities, the dependence model seems to be related to substance use. In other words, behavioral and chemical addiction cause many of the same processes and changes in brain chemistry.  Some scientists even suggest that the dopaminergic pathway is more influential than the opioid system. That is the desire for the behavior/drug can be many times more powerful than the joy obtained from the behavior/drug itself. Continued execution of these addictive behaviors further exacerbates their signals and desires, partially damaging the prefrontal cortex and impairing impulse restraint. In this way, dopamine enhancing activities like sugar, masturbation, etc. become easier and easier to say “yes” to. I think modern society is becoming more and more inclined for these dopamine surging effects. And its clear to see that much of our everyday activities have been designed to be addictive; fast food, Facebook/SM, gaming, TV, high-speed web surfing, etc. Many recent studies have shown that these factors directly influence life satisfaction. Moreover, a strong correlation between these activities and the increase in the diagnosis of anxiety, depression, ADD, and ADHD in all ages have been confirmed [study]. For me it seems obvious – the rate of technological advancements is far exceeding the progression of our monkey brain. Fortunately, with a growing understanding of these neuroscientific concepts, people are becoming more aware and choose to avoid frequent use of these activities – leading to the “restoration” of long-term dopamine-abused receptors. This can be recognized through the emergence of groups such as “No Fap” – where thousands of men (and women) are vowing to quit pornography, masturbation, and orgasm in order to restore their genetically available levels of dopamine receptibility. Similar support groups can even be observed for gaming, gambling, smoking, and many more, all of which are recognizing dopamine key part in these activities. This has similarly resulted in these groups partaking in what’s known as a “dopamine fast” avoiding; mobile phones, televisions, food (basically anything pleasurable) for a 24 hour period. This article study explores the techniques, methods, and nutrition of how to naturally repair dopamine receptors and how to stimulate the process. That being said, there is no magical resolution and the most essential part of the restorative process is eliminating dopamine increasing behavior.  

    What Are The Best Nootropics to Repair Dopamine Receptors?

     

    #3 Uridine

    nootropics for dopamine recovery There is evidence that uridine can regulate dopamine levels through the up-regulation of striatal D2 receptors [study]. User reports state that it can reduce the symptoms of depression and bipolar disorder while improving people’s perceived level of well-being. Furthermore, uridine has been shown to help those overcoming cocaine addiction revealing a increased recovery rate . Many studies examining the effects dopamine desensitization have found that uridine supplementation can have a positive impact at reducing dopamine desensitization, two studies of which concluded;
    ‘This study reveals evidence that chronic uridine may alter drug-induced dopaminergic activity without exerting negative effects. ‘
    ‘In conclusion, these data suggest that the therapeutic effects of uridine on the dopaminergic system possibly through its agonistic nature on GABAA receptors.’

    Benefits and Uses of Triacetyluridine 

    • Promote a sense of well-being
    • May help promote cognitive well-being
    • May help promote healthy stress levels
    • May help increase motivation

    Triacetyluridine Dosage

    Dietary supplementation of 25mg of Triacetyluridine daily.  

    Best Nootropics to Repair Dopamine Receptors 

    #2 CDP-Choline (Citicoline)

     

    nootropics-for-dopamine-repair

    The brain needs a whole lot of nutrition when performing mental tasks. Citocholine provides a bioactive source of fuel for such events. In layman’s terms, it is the chemical that allows you to stay focused throughout the day.
    Choline is a naturally occurring precursor to acetylcholine and is a component of normal brain function. CDP Choline (aka Citicoline) is used as a highly-bioavailable form of choline and can be purchased at nutrition pharmacies. It is also often used for its ability to prevent age-related memory decline. Citocholine has been clinically tested to show signs that support attention, memory, and dopamine receptor density.  

    Studies & Evidence of Dopamine Receptor Repair

    Mice given 100 mg/kg CDP choline daily for 7 months were observed to experience D2 dopamine receptor density increase by 11% [study]. Human subjects treated with 500 mg/kg per day, D2 receptors increased by 18%[study].  

    Citicoline Benefits

    Citicoline supplementation may include:

    • Improved memory
    • Enhanced learning capacity
    • Increased focus and attention
    • Faster recall speed
    • Combat mental fatigue

    Dosage 

    Citicoline 2x250mg daily as part of a normal diet

     

    Natural Sources

    Natural sources of choline have vastly different capacities to penetrate the blood-brain barrier. Nevertheless, some natural sources contain fair amounts of this brain-boosting compound.
    • Egg yolk
    • Butter
    • Nuts (pistachios, cashews)
    • Pumpkin seeds

    Possible Side Effects 

    The possible side effects of too much choline are tension headaches. This occurs in a small percentage of the population and these users are suggested to source choline through dietary measures only.  

    #1 Best Nootropics to Repair Dopamine Receptors 

     

    ALCAR (Acetyl-L-Carnitine)

    dopamine D2 receptor upregulation When it comes to Nootropics to Repair Dopamine Receptors look no further than acetyl L-carnitine. Acetyl L-carnitine, also known as ALCAR, is the acetylated form of L-carnitine, that is it is made after a chemical reaction has been performed, adding an acetyl functional group to L-carnitine. L-carnitine is an amino acid naturally occurring in the diet and often supplemented before working out. Acetyl L-carnitine is better absorbed than standard L-carnitine.  

    Studies & Evidence of Dopamine Receptor Repair

    Here are some recent findings that examined the effects of Acetyl-l-carnitine;  
    Via upregulating dopamine D1 receptors and attenuating microglial activation, acetyl-L-Carnitine  was shown to prevent neuronal loss and improve memory in Parkinsonian rodents L-Carnitine significantly reduced impulsive behavior in dopamine impaired ADHD rats

    Reversal of  memory loss symptoms in old rats after feeding acetyl-L-carnitine

    Acetyl-l-carnitine improves spatial learning in senescent rat subjects  

    Benefits

    The natural production of L-carnitine in the body has been seen to decrease over time, resulting in the impairment of mitochondrial function. Acetyl-L-carnitine supplements can help to reverse this process and boost energy in fatigued individuals. Energy is one of the most well-reported benefits of many acetyl L-carnitine, and users report that can additionally improve cognitive performance whilst reducing physical fatigue.  

    Mechanism

    Acetyl L-Carnitine is known to promote mental energy and is recognized as a natural intelligence enhancing supplement. Its benefits are derived from the increased transport of fatty acids into the mitochondria of the cell enabling brain cells with an increased energy supply. Acetyl-L-carnitine has also been found to have neuroprotective effects in the brain, resulting in improved tissue health and brain cognitive function.  

    Dosage 

    1x 500mg Acetyl L-Carnitine HCL capsule daily.  

    Nootropics to Repair Dopamine Receptors – Final Thoughts

    Nootropics to repair dopamine receptors are being used by more and more people due to their strong neurodegenerative and neuroprotective characteristics. This article uncovers and examines the latest available research concerning these unique brain-altering compounds and their effect on the recovery of dopamine D1 and D2 receptors. The research in this field appears very promising and the medical interventions for such compounds are being clinically trialed for their ability to assist recovery in certain drug and behavior addictions, as well as age-related cognitive and memory decline. The most effective substances shown to produce this growth of receptor density are considered to be acetyl-l-carnitine, citicholine, and uridine.  
    nootropics improve social anxiety -phenibut

    Nootropics For Social Anxiety: 5 Best Options

    Nootropics For Social Anxiety – can they really be effective? We all recognize that if you want to communicate with fluidity and precision, sharp attention skills and quick wit are a must. One must have a keen focus on the other individual – adapting to suit the environment, atmosphere, and conversation subject. But many find themselves constantly thinking about what they should or shouldn’t say. “Am I talking too much?/ Am I talking too little?/ Did that sound weird?”. These are all examples of some of the internal thoughts that can pass through the consciousness of a socially anxious individual. And it is undeniable that this internal dialog can have disastrous effects on your communication, destroying your capacity to enjoy lucid, gratifying conversation.   That’s why I support the supplementation of specific nootropics for social anxiety – shown to help calm your nerves and unleash your natural charisma. Many like myself are now realizing the true power behind nootropics for social anxiety and have utilized them for their ability to grow intellectual power and spruce thoughts!  

    Nootropics For Social Anxiety #5 – L-tyrosine

    nootropics for social anxiety - L-tyrosine Talking with people at work or in meetings throughout the day can create unwanted stress in the brain and body. L-tyrosine is an amino acid that is shown to help your brain during these situations – allowing users to continue to function at a high-performing level without getting tired during stressful events.  L-tyrosine can provide your brain with essential building blocks to help replenish the neurotransmitters affected by mental stress and through this action, can ultimately lead to a reduction in mental tension, increased work capacity, and of course, alleviation of social anxiety. The mechanism of action works in a few different ways, essentially concerning the storage of stress neurotransmitters, norepinephrine, dopamine, as well as serotonin.  This is very important in combating the negative effect caused by stress as even small discrepancies in these chemicals can cause mental fatigue, distraction, and/or depression.  L-tyrosine given at a dosage of 68 mg per pound (150 mg per kg) of body weight per day for up to three months has been shown to have shown to be safe, although users are advised that this supplement may interfere with some prescription medications such as MAOIs.  

    #4 – Nicotine 

    nootropics for social anxiety -nicotine Believe it or not, one of the best nootropics known to alleviate that social unrest is nicotine! Epidemiological studies have shown the therapeutic potential of nicotine since the 1980s, where it was found that smokers had a lower incidence of Parkinson’s disease than non-smokers. Epidemiologists also confirmed that many mental health practitioners have long realized that smoking rates among patients with schizophrenia, depression, and anxiety are much higher than average. Although instead of considering this a correlation, it is generally thought that people with certain mental health problems are inclined to use tobacco for self-treatment purposes. This is because studies show that nicotine can actually help this population to perform better. I know it may sound crazy. After all, nicotine bad for you, right? Correct! If you get smoke from tobacco, that is. Tobacco is full of toxins such as tar and carbon monoxide, as well as very high levels of nicotine – which as we all know, can be very addictive. However, a small amount of nicotine (500mg a day) may be what the doctor ordered, so to speak. Dosages this minuscule are believed to provide mental energy, cultivating a healthy approach to any social situation. It is also found that nicotine can improve;
    • Short-term memory
    • Reaction time
    • Vigilance 
    Now it is no doubt that these symptoms can play a role in making you feel more comfortable and confident when socially interacting, although scientists seem to suggest a direct correlation in the reduction of stress neurotransmitters in the brain suggesting that nicotine has the potential to act as a neurological defense against mental stress.   Some healthier nicotine options include spays, patches, or gum – all in which remove the carcinogenic effect of tobacco smoke.  

     #3 – Phenibut

    nootropics improve social anxiety -phenibut Originating from Russia, Phenibut is believed to be effective as an anti-depressant as well as a cognitive stimulant (nootropic). This nootropic effect of the drug is known to enhance function and improve intellectual performance as well as significantly relieving stress. It works very similarly to alcohol, as it drastically impacts the function of GABAB and to a lesser degree, GABAA receptors. This will produce an overall sedative effect on the user. Those considering this nootropic should be aware that phenibut is known as a sedative nootropic, which in other words, means it can relieve stress, tension, and bring a feeling of lightness and relaxation – resulting in the sensation of being drunk (without that intoxicated sensation). In my experience, this is certainly true and is what makes this nootropic one to be extremely wary of! Similarly, it has been shown to enhance dopamine in neurotransmitters an effect that will improve one’s mood and motivation – inspiring him/her to be happy, positive, and positive.  The recommended daily allowance is 250 mg however, recreational users have reported taking amounts of up to 3000mg – A dose that will undoubtedly produce a very drunk sensation.   Caution! Because of its mechanism of action, Phenibut is extremely addictive both physically and emotionally. Users are advised to supplement with phenibut only when absolutely necessary. This will negate the potential for addiction and help to avoid tolerance. Anecdotal reports suggest one who doses more than two times per week is at high risk for dependency.    That being said, I can advocate for the powerful anti-anxiety effects of phenibut and utilize this compound several times per year (mostly before presentations at work). I have found that the absorption is highly dependent upon the stomach contents – so it is most effective to dose on an empty stomach ( at least 3 hours after eating).  

    Read more: Nootropics For Motivation

    #2 – Noopept 

    Noopept is a cognition-promoting supplement of the racetam family, known well by the nootropic community for its capacity to induce a sense of calm lucid thought.  The drug is shown to have quick-acting and powerful mood-lifting effects. This is because it is easily absorbed into the blood and quickly moves to the brain, passing through the blood-brain-barrier providing its anxiolytic, calming effect almost-immediately. This speed of action is of great interest to medical researchers as it could potentially be very useful in treating those who suffer from panic attacks. This is because often the attacks are spontaneous and extremely difficult to control/predict (and of course are extremely uncomfortable). The suggested mechanism of action includes; increasing the signal transduction of acetylcholine, BDNF and NGF expression, prevention of glutamate toxicity, and increased inhibition of neurotransmission in the brain. Not only can Noopept promote improved cognition and calmness, but it also has been recognized for its potential help maintain brain health by increasing the neuroprotective factors within brain cells! Further research has supported this notion, showing that people who already have cognitive and mental difficulties can make significant progress after supplementing with Noopept – making it effective in the short-term treatment of anxiety.  

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      Nootropics For Social Anxiety #1 – L-Theanine 200mg

      Nootropics For Weight loss Have you ever drank a big cup of green tea, only to find that you feel more calm and focused? This is due to the natural ingredient, l-theanine, which has been shown time and time again to relax and improve concentration in human and animal subjects.  It is also to be noted that scientists have found L-Theanine and caffeine to be synergistic, meaning when combined, they can produce a host of favorable effects. Some of these include;
      • increasing reaction time (eg, the speed at which words are processed)
      • improving memory
      • reducing mental fatigue 
      These effects are clearly essential for achieving fluid speech and conversation – the only problem is, you’d have to drink a lot of green tea to enjoy the full potential of L-theanine!  So, if you’re like me and enjoy the calming effect that green tea provides, perhaps an l-theanine nootropic supplement is a right choice for you in improving anxiety.   Clinical research has examined and confirmed effectiveness at dosages around 200mg/day.   

      What Nootropics to Avoid For Social Anxiety

      Caffeine – While it does provide a good pick me up after a lazy lunch, caffeine is one chemical many socially anxious individuals should keep clear of. This is primarily for the fact that caffeine elevates the stress hormones in your body, exacerbating the already stimulated central nervous system and worsening symptoms of unrest. Modafinil/Adderall – Those suffering from anxiety should avoid potent nootropic stimulants as they have a high potential to increase your heart rate and cortisol levels. Alcohol – it may seem like a good spice to eliminate social unrest, but it damages your cognitive function causing clear impairments in memory not only will you forget what the conversation was even about, but you may end up saying something that you regret!  

      Conclusion 

      Nootropics are well known for their various effects throughout the brain and body. Of late, nootropic supplements have received attention for their ability to improve symptoms of social anxiety amongst users. Some of the best nootropic supplements for social anxiety disorder are; L-theanine, L-tyrosine, Noopept, phenibut, and nicotine. All of these have various effects throughout the body and users should experiment with caution.  
      Nootropics for Weight loss

      Nootropics for Weight Loss

      Recently nootropics have been praised for their strong ability to increase cognitive performance, motivation, and mood in users.

      However, did you know that some clinical trials now show that certain nootropics are effective for weight loss?

      There are several things to consider before trying a Nootropic for Weight loss and in this article, we will go over everything you need to find your perfect nootropic for weight loss. No matter your fitness goals! As well as their strong effect on cognition, nootropics are becoming more and more well-known by the fitness community for their ability to enhance work out intensity, improve focus, and overall performance. It is no doubt that nootropics can play a key role in our ability to place attention on specific tasks, however many fitness gurus are now advocating the use of certain nootropics for the purpose of improving overall workout effectiveness and weight loss. Can this be true? Let’s look into what science has to say about the effectiveness of nootropics for weight loss.  
      Disclaimer: you are reminded that this guide is not for the purpose of medical treatment and before taking any supplements it is advised that you consult a healthcare professional.
       

      Can Nootropics Help with Weight Loss?

      A 2010 study titled “Citicoline Affects Appetite and Cortico-Limbic Responses to Images of High-Calorie Foods” looked at the relationship between nootropics and weight loss supplements to uncover some interesting details behind what may happen following ingestion. The primary test molecule was citicoline, a popular compound known for the ability to enhance dopamine in cocaine-addicted subjects and greatly assist with recovery addiction. The groups were split in 2 with individuals either receiving 500 mg or 2000 mg of Citicoline. It was then observed that the group receiving a larger 2000mg dosage had noticeably less activity in the amygdala, insula, and the lateral cortex. This diminished activity within these brain regions was seen to coincide with a decrease in levels of appetite amongst the individuals.  

      Should I Try Nootropics for Weight Loss?

      When considering a nootropic for weight loss, it is first essential to consider how much weight you would like to lose. It is also crucial that you critically analyze your diet and eating patterns before attempting to assess things to change. If you are someone who struggles with the temptation to eat too much and too often, perhaps nootropics can assist you in fighting off those urges.
      Please note that there are many known natural appetite suppressants available. However, if you are someone who already benefits from the effects of nootropics or is interested in their wholistic effect, then read on.
       

      Which Nootropics to Take for Weight Loss?

      Deciding the perfect nootropic for you lies in the ability for you to determine what your body needs. Often when we suffer from appetite irregularities the source may be related to dopamine neurons firing in a less optimal way. In this situation, it seems very plausible to think that nootropics can assist in decreasing food intake.  

      #3 Citicoline

      Citicoline is commonly found in nutritional supplements and is available in many health food stores around the globe. It is an organic compound which has been researched in animal and human subjects to show a clinical increase in;
      • Cognition
      • Neuroregeneration
      • Neuroprotection
      Citicoline is even reported to have a significant impact on the elevation of motivation. This is demonstrated in preliminary research where Citicoline supplementing participants were significantly more likely to feel motivated and enthusiastic when confronted with a challenging task. You can read more about Nootropics For Motivation here.  

      Mechanism

      In the small intestine, ingested citicoline will undergo a process known as hydrolysis, resulting in the high absorption of choline and cytidine (95-100%). It is believed that these molecules then enter the brain via the blood-brain barrier to assist in the preservation of cell membrane phospholipid catabolism. This achieved by increasing the synthesis of acetylcholine and phosphatidylcholine which are primary membrane components. While scientists are still not certain, it is thought that this process has an effect on the dopamine reward system which can lead to reduced cravings and diminished urges to eat.  

      The bottom line

      Preliminary findings reveal that a dosage of 2000 mg/day of citicoline for a period of 6 weeks is associated with a significant drop in hunger amongst healthy patients. This supplement is readily available and passes the consumer health laws of many countries.  
      {Read more: Nootropics For Anxiety}
       

      #2 Caffeine

      Did you know that coffee contains a complex chemical concoction of more than 1000 unique compounds? Nootropics For Weight Loss We’ve all heard of it and probably have consumed it, however, 1,3,7-trimethylxanthine (caffeine) still holds many mysterious effects in the body that we are unfamiliar with. That being said, caffeine has been vigorously studied and is well-known for its ability to improve mental cognition, reaction speed, endurance, and additionally, weight loss. Yes that’s right, weight loss too! This has been identified through the noticeable increase in the number of calories burnt at rest in participants who had ingested caffeine [study]. But the fat burning ability of caffeine doesn’t stop there! It has also demonstrated the potential to improve the body’s capacity to metabolize fat cells, a process primarily achieved through increasing norepinephrine levels in the blood and increasing circulation to adipose tissue. In effect, this encourages the body to prefer the breakdown of fat for energy. Moreover, some research appears to suggest unusual features about the effects of caffeine. Some studies now suggest that male subjects may react differently to the drug. This evident in one study that found that after consuming 300 mg of caffeine, men will likely decrease calorie consumption by up to 22% whereas this effect was not evident in female subjects.

      Don’t worry ladies!

      Studies continue to report that resting metabolic rate in both sex patients can be increased by 11% for up to 24 hours following ingestion. Regardless of gender! It should be noted that in these studies caffeine alone was not enough to induce overall weight loss results.  

      The bottom line

      The decision to consume caffeine or not should primarily depend upon your personal preference as well as experience with caffeine. While there is currently limited evidence to suggest that caffeine consumption amongst healthy users will produce any adverse side effects, anecdotal reports suggest that some individuals may experience negative impacts such as increased symptoms of anxiety and jitteriness. Nevertheless, there is no doubt that caffeine can increase the metabolism of fat and thereby is useful for those trying to lose weight.    

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        Nootropics for Weight Loss #1

           Nootropics For Weight loss  

        Green Tea Extract

        Green tea – Well known for its nootropic substituent L-theanine, is speculated to contain several distinct compounds likely to enhance weight loss. Much of the research around this topic focuses on catechins, particularly epigallocatechin gallate (EGCG) which are commonly extracted from the tea leaves and included in the many commercial weight loss supplements available in the store. A quick search around the net shows that the fat-burning effect is heavily advocated by many in the bodybuilding industry and good reason! Popular research platform, PubMed reveals over 224 articles acknowledging the health-promoting benefits of green tea, with much of the research finding that it has an overall enhancing effect on weight loss. One of the more popularly cited articles state;
        “On the basis of these results, one can advance the notion that EGCG is readily available and widely consumed and may have a high potential use in the prevention of metabolic syndrome.”
        (From Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome)  

        The bottom line

        EGCG (which is found in green tea), has been consistently observed to assist subjects aiming for weight loss. Studies using dosages of between 300–460 mg of EGCG for at least 12 weeks are shown to be the appropriate conditions for significant, noticeable increases in fat metabolism and weight loss.  

        Conclusion

        There you have it, the very best sourced nootropics that have all been clinically shown to possess fat-burning effects. All in which you can start using to assist you in your weight loss goals today! Nootropics for weight loss is a growing area of research and future research should focus on other various naturally occurring nootropics to determine their effect on fat metabolism and weight loss. The prospect behind nootropics and their effects are exciting and it is quite possible that in the future these supplements may be recommended by doctors for their ability to assist in the prevention of mental health deterioration as well as weight loss! If you have any questions regarding this topic or have tried some of these compounds yourself, let us know your experience down in the comments below!   
        Nootropics For Motivation

        Nootropics For Motivation: 5 Best Options

          Do you feel it too? Those persuasive urges that tell you, “just one more episode“. But you know what needs to be done… It’s just that brain of yours convincing you otherwise, again. Feelings like this are leading more and more people like you to research the effects of Nootropics for motivation, in the hope that one day they too can kill that unmotivating mood and get on with life’s goals. So if you do a quick search around the web you’ll quickly find that there’s a lot of hype around nootropics for motivation and their alleged boosting powers. So, unsurprisingly more and more people are starting to ask the same question: “What Are the Best Nootropics For Motivation?”. After a solid amount of research, we’ve come up with the top 5# Nootropics for Motivation that you can look into trying yourself!
        Note that the information given is not to be considered medical advice. Please consult your doctor before trying any supplements
         

        Are Nootropics Effective for Motivation?

        In short, yes. But the benefits behind nootropics stretch well beyond the scope of simply enhancing motivation – most users even go as far as saying that nootropics completely killed their mentally disabling anxiety (read more here). And these claims have been backed up time and time again by clinical research. But which are the best nootropics for motivation? And which ones have been well-researched? In this article, we go over everything you need to know about picking the right nootropics for motivation. This will give you a completely honest, and free guide on ways to boost your motivation using nootropics. We will be considering toxicity and research as the number one priority when creating our top 5 Nootropics For Motivation.  

        #5 Nootropic For Motivation is…

         
        1,3,7,9-Tetramethyluric Acid or more commonly known as… 

        Nootropics For Motivation - Theacrine (1)

        Theacrine

        Also known as 1,3,7,9-Tetramethyluric Acid, Tetramethyluric Acid or 1,3,7,9-Tetramethylpurine-2,6,8-trione.
        Theacrine, as covered in “Best Nootropics For Anxiety”  can not only treat anxiety disorders but it is thought to be one of the best options when considering nootropics for motivation! Theacrine has also been seen to improve;
        • Anxiety

        • Cognitive Performance

        • Situation Analysis

        • Reaction time

        • Thought processing and much more…

        Many suggest that the motivation boosting effects of theacrine are due to its tendency to cause mild-moderate euphoria, although science now shows that Theacrine can affect dopamine D2 receptors in the brain, which enhances the ability to recycle dopamine. This can ultimately lead to the dissolving of symptoms related to lack of motivation including; task avoidance and resistance to perform difficult duties.

        In effect users often notice a higher perceived reward for tasks that normally seem less appealing, anecdotally enabling users to “smash through” their less interesting jobs.

        Sources of Theacrine

        Theacrine is most commonly known as a natural component of the Camellia assamica tea plant (var. Kucha.). Still, it is found in lesser amounts amongst various types of tea and coffee.

        Theacrine Dosage

        The in-plant form of theacrine from the Kucha plant is 36 mg/g. To find how much theanine your consuming,  simply multiply each gram of tea brewed by 36! For many, 300mg/day has been an optimal dosage. There are of course, high-quality supplement options available to support ease of dosing. We recommend a brand that has been third-party tested

        Safety

        Research shows that 300mg of theacrine per day for a period of 2 months does not cause symptoms of tolerance or addiction. That being said, we believe that cycling supplements are the most effective way of getting bang for your buck, so be sure to take periods off all substances. This applies even caffeine… Read more about
        Reasons why anxious people should quit caffeine today!  

        #4 Nootropic For Motivation is…

          Hint: An amino acid found in cheese, milk, and beef. It is used to improve alertness, attention, and focus. Nootropics For Motivation - l-tyrosine

        L-Tyrosine

        Our list of best Nootropics For Motivation wouldn’t be complete without this one and for good reason! L-tyrosine takes our #4 position when considering top supplements for motivation as it is literally the body’s “building block for dopamine”  aka the “motivation neurotransmitter“. L-tyrosine’s mechanism of action in the brain lies in its fundamental role in producing L-DOPA, which then is processed to dopamine. This will allow users to benefit from increased dopamine levels which seemly improves gratification received from task completion. It is also commonly used to manage perceived stress levels in anxious and depressed subjects.

        Benefits

        Upon supplementation, L-tyrosine has been well known to improve aspects of;
        • Stress
        • Cognitive capacity
        • Sleep
        • Mood

        Dosage

        To experience the maximal dopamine boosting benefits of l-tyrosine, it is recommended that users dose between 45-68 mg per lb of body weight (or 100–150 mg per kg).
        Note this supplement can be of particular value during the anticipation of a stressful event. If taken roughly 1-hour prior to the event, users can experience significantly less stress and higher levels of motivation.

        Safety

        Short term studies reveal that L-Tyrosine is considered unlikely to produce any health concerns when used as recommended. Some adverse side-effects to pay attention to include; vomiting, indigestion, headache, joint pain; or and fatigue which can occur in some individuals at higher doses.  

        #3 Nootropic For Motivation is…

          Hint: In the cold and mountainous areas of Europe and Asia, this plant thrives. Nootropics For Motivation - Rhodiola

        Rhodiola Rosea

        Rhodiola Rosea aka “the golden root” is a traditional secret of Russian/Scandinavian indigenous that has been used for centuries! It has mostly been commended for its capacity to improve mood and memory as well as eliminate fatigue, poor concentration, and distraction. These effects have been well confirmed by the scientific community with evidence revealing a significant ability to allow subjects to work more efficiently when given tasks to complete.
        “Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer.” [study]

        Benefits

        Rhodiola Rosea extract has been found to support a wide range of health outcomes with research indicating the following benefits;
        • Reduce anxiety & depression
        • Reduced fatigue
        • Increased motivation
        • Treatment of Diabetes
        • Alleviating altitude sickness
        • Improvement of athletic performance

        Mechanism

        The mechanism for such diverse improvements in symptoms of fatigue and depression are still not well understood although evidence suggests that it could be due to the way Rhodiola can dramatically influence the stress hormone, cortisol. This is believed to assist with the body’s natural defense against physical and psychological stressors, offering a sense of freedom to the user. Some various control studies (both test-tube and in humans), have suggested that Rhodiola can support hundreds of aspects of health. Some research using rats even suggests that it could even be effective against treating diabetes.

        Dosages

        Most research showing the benefits of Rhodiola use a dosage of 3 mg per kg. This equates to between 200-400mg. Nevertheless, whether taking Nootropics For Motivation, or anything else it is important to practice minimal effective dose as discussed here.

        Safety

        Overall, Rhodiola is a plant that offers numerous health benefits. When taken in the suggested dosages it can be deemed safe with a low prospect of having adverse health effects. After thorough toxicological research, Rhodiola has been certified both safe for consumption in both animals and humans
        Looking to purchase Rhodiola? Look for brands that have known third-party testing! This will avoid potential contamination in your supplement.
         

        #2 Nootropic For Motivation is…

          Hint: This has nootropic has been recognized for its ability to alleviate & prevent dementia in rats.

        Nootropics For Motivation - Nefiracetam (1)

        Nefiracetam

         

        What is Nefiracetam?

        Nefiracetam is a compound heavily studied for it’s potential to improve the memory of patients with Alzheimer’s disease. Originating from the racetam family, Nefiracetam has demonstrated an entire host of thought-provoking results when given to subjects. These include;
        • Increasing the recycling of dopamine in the cerebral cortex and striatum
        • Boosting the activity of choline acetyltransferase in the hippocampus (improving memory formation and learning)
        • Managing symptoms of ADHD
        One study mentions that preliminary trials on Nefiracetam were found to cause;
        “an improved patient outlook and energy following stroke.”
        This was evident by the increased motivation observed after treating the post-stroke patients with Nefiracetam. Similarly, Nefiracetam has been found to exhibit anti-amnesia effects on dementia patients, particularly the Alzheimer’s and cerebrovascular type. Research even suggests that it is effective at alleviating the negative impacts against a number of memory impairing substances, including ethanol, picrotoxin, chlordiazepoxide, scopolamine, bicuculline, and cycloheximide. All in which are known to reduce cognitive capacity. 

        Source

        Nefiracetam, like all racetam compounds, is synthetically created. It can be purchased online or can be prescribed by a doctor.

        Mechanism

        Nefiracetam acts by potentiating (PKCα) protein kinase C alpha. In addition to this, a 200% increase in L-type Ca2+ channel currents have been noted. In effect, this leads to the strengthening of neural connections associated with memory (Ca2+/calmodulin-dependent protein kinase II (CaMKII) pathways) You can read more about the mechanism of action from fellow nootropics expert here.

        Dosages

        Clinical research has experimented the effects of dosages starting from 150mg up to 450mg over the course of a day. There has been limited evidence to suggest adverse reactions at these levels.

        Safety

        Long-term studies on the consumption of nefiracetam in humans and primates have determined no toxicity. It is commonly sold as an Alzheimer’s treatment in Japan and can be purchased over-the-counter in some states of the USA, however not as a supplement.  

        Want Your Free Guide to Nootropics?

        Get It Here

           

          #1 Nootropic For Motivation is…

            Hint: a plant that has long been used in the traditional Indian medicine of Ayurveda. Nootropics-For-Motivation-Bacopa-monnieri

          Bacopa monnieri

          Bacopa (aka brahmi), is a plant that has is commonly used to treat Alzheimer’s disease. It can also assist in:
          • improving memory
          • Improving motivation
          • Reducing anxiety
          • Treating attention deficit-hyperactivity disorder (ADHD)
          • Decreasing inflammation (especially in the brain)
          • Improve the ability to process visual information

          How does it work?

          Bacopa is thought to enhance certain brain chemicals that are involved in thinking, learning, and memory. Research suggests that it is likely to also preserve brain tissues from the plaques involved in Alzheimer’s disease. Such benefits are produced by compounds known as ‘bacosides’, which are the main active compounds of Bacopa monnieri. These have been shown to act as a powerful antioxidant in the body and have been noted for their potential to neutralize free radicals and inhibit fat molecules from reacting with free radicals, preventing a process known as lipid peroxidation (which is linked to the formation of several neurodegenerative disorders including Alzheimer’s and Parkinson’s disease). Furthermore, supporting this is another study looking at the effect of bacosides in rats which revealed that reduced signs of free radical damage and reversed signs of memory impairment can be observed in subjects suffering from dementia.
          In humans, a 12-week study in 46 healthy adults observed that taking 300 mg of Bacopa monnieri daily significantly improved the speed of processing visual information, learning rate, and memory, compared with the placebo treatment This is supported by another 12-week study that found that adults taking either 300 mg or 600 mg of Bacopa monnieri extract daily had experienced a significant increase in memory, attention, and the ability to process information when compared with the placebo treatment.

          Dosage:

          The majority of clinical analysis has determined evidence to support the effectiveness of dosage between 300mg-600mg.

          Safety:

          Short term use of bacopa extract is classified as “probably safe” for adults when taken orally in the prescribed dosages.  
          One should be aware of the common side effects of Bacopa which may include; fatigue increased bowel movements, stomach pains, nausea, and dry mouth.
           

          Conclusion

          There you have it. Our top #5 Nootropics For Motivation. Please note that all individuals react differently to various substances and even though clinical studies may reflect promising benefits, effects are different for everyone. Because of this we advise potential users to start at the lower end of dosage recommendations and always consult a healthcare professional before consuming any nootropics for motivation. So which ones have you tried? Let us know your experience in the comments below!    
          Top Nootropics For Anxiety.

          Nootropics for Anxiety: Ultimate Guide

          After trialing numerous natural ways to free myself of anxiety I decided to research Nootropics For Anxiety and run a little experiment.

          I noted changes in anxiety levels across categories; social, performance-based, and general-based, to categorize my levels of anxiety across everyday events.

          Could Nootropic’s really be able to assist my ability to manage levels of anxiety and depression? I documented my experience in all of its glory, noting my findings, realizations, and mood changes throughout this process. All to which I reflect on while writing this. I think you’ll find this to be the most in-depth Nootropics For Anxiety Guide available on the internet.

          May you too start winning the battle over anxiety today🧬.

           Nootropics For Anxiety Swixis

           

          How Thousands are Reducing Anxiety with Nootropics

          I know how it feels. That lingering monster talking in your ear. It’s the one who tells you those convincing stories about things like why it is better to stay at home and avoid that event/outing.

          It even the thing that makes you think, “What if that person didn’t like what I said” or makes you afraid of “looking stupid”.

          Whether big or small anxiety loves to creep into our lives and if left unattended it can grow, manifesting into what we begin to believe is part of our personality. So for most, it becomes just that. Another characteristic of who they associate “themselves” to be…

          Thankfully, science is now showing some promising ways to regain that lost sense of balance.

          Nootropic supplements have been increasingly praised for their ability to assist users in achieving their first anxiety-free day in many years. Not only this, but many now say that they have also experienced things like; greater mental efficiency, clarity, and an improved sense of natural charisma.

          Users also report an ability to conceptualize situations “uniquely”, which reportedly improves anxiety during “triggering times”. These include things like the completion of tasks, assignments, and when required to socialize smoothly.

          More and more people, like me, are using Nootropics For Anxiety, and believe it or not, it might work better than you think.

          *note while there are many well-documented ways to improve anxiety, we will be discussing the use of Nootropics For Anxiety treatment specifically. Always consult your doctor prior to starting any supplementation.

           

          What Are Nootropics?

          “Nootropic” is the term used to group a list of various natural and synthetic compounds of both diverse structure and effect. The commonality is that all leave users describing an optimized sense of mental performance. And they’re pretty right as many have been shown to score higher on cognitive tests (link). They can be classified by their various mechanisms of action in the body and consequently have become a hot point of interest throughout the science community.

          So, there are many many types of Nootropics, which can all have various effects.

          But which one is right for you?

           

          Can Nootropics Help Anxiety?

          Nootropics are compounds which when consumed have been well-documented to;

          • Improve Cognitive Function
          • Improve Working Memory
          • Increase Creativity
          • Improve Mood
          • Lower Anxiety

          But which one should you Take?

          Choosing your nootropic supplements can be tough. There is so much information out there and it’s hard to know who to trust.

          Beware: I often see content written by people who are solely trying to sell you their supplement and misrepresenting the evidence.

          I offer my unbiased opinion as a medical scientist who has experimented with Nootropics at home.

          Here’s what I have to say…

          Choosing the best Nootropic For Anxiety relies firstly on knowing which ones to avoid.

           

          Which Nootropics to AVOID For Anxiety 

          If you want to be your most efficient, mentally sharp, anxiety-free self there are some common mistakes that you must avoid.

          All too often people start with the question “what can I take to fix ____” without ever considering “what can I stop taking to fix ____”.

          Optimizing yourself relies on your ability to feel you 100% natural baseline before trying to change it.

          And the most well-documented Nootropic to increase anxiety is…

          Best Nootropics For Anxiety

          #1 Caffeine

          That’s right, who would have guessed!

          How many times have you smashed down that cup of joe only to sense that among your buzzing sense of satisfaction, you were wrapped in a jittery sense of tension. It’s the kind of feeling that likes to lay low but will make your heart race when thinking about that thing you that been bugging you.

          I hadn’t had a caffeine-free day in so long that I forgot what it felt like to have zero caffeine in me – (this can take well over 2 weeks if you drink coffee or energy drinks every day).

          Nevertheless, whether you like it or, not caffeine is not part of an anxious person’s life.

          Things to avoid/reduce include;

          • Cola – all types (sugar-free, diet, etc)
          • Coffee (crazy right?)
          • Chocolate (although not much caffeine, during a Caffeine Cleanse chocolate should be avoided).
          • Energy drinks (don’t drink these)
          • Green/Black/Chia Tea

          If your someone who likes to be at their mental peak dealing with caffeine withdrawals is the last thing you may want to do. However, in my experoemce once you kick this habit your reduced anxiety levels will give you back 130% of that alert, high performing mental state that coffee offers. This will be completely free of any crash of course.

          So now that we have addressed the most common mistake anxious people make with nootropics let’s talk about what you can take.

           

          Best Nootropics for Anxiety

           

          Nootropic For Anxiety #3 -Theacrine

          Found primarily in the leaves of the Camellia assamica var. kucha Chinese tea plant, theacrine has recently shaken the fitness and biohacking community for its ability to act as a stimulant—without the typically occurring undesired jittery side effects.

          The compound appears to be synthesized from the caffeine molecule in some plants during growth, and is reported to assist users with;

          • Reduced Anxiety
          • Cognitive Analysis Enhancement (improved ability to process information)
          • Improved reaction time and thought processing
          • Mild-moderate euphoria
          • Motivation increase
          • Increased alertness
          • Heightened music enjoyment
          • Focus intensification –  this effect tends to be more noticeable when compared to caffeine
          • Heightened libido
          • Memory improvement

          Compared to caffeine theacrine has the following advantages;

          • Absence of fluctuations in blood pressure or heart rate.
          • Extended half-life.
          • Absence of jittery sensation.
          • Much less potential for tolerance growth and addiction.
          • No perceived come down – caffeine has been shown to have a much stronger “crash”.

          This study supports these observations stating that “Theacrine supplementation has a favorable impact on multiple subjective feelings related to energy and mood”.

          Safety: Theacrine is known for its extremely low toxicity in the body. Various studies have shown that in reasonable doses similar to that found in tea, the compound presents no adverse cognitive, psychiatric, or toxic consequences. I can attest as one who has not suffered any negative impacts.

          Recommended Dosage: 1,3,7,9-tetramethyluric acid (Theacrine) = 300mg

          • Most research shows optimal performance with the least side effects when taken at 300 milligrams of theacrine per day. Studies show that even after 60 consecutive days at 300mg participants did not develop a tolerance or reliance.

           

          Nootropic For Anxiety #2- Phenylpiracetam 

          Warning: Be it legal in the United States, phenylpiracetam is not approved by the FDA as a dietary supplement. It is on the list of drugs banned for “in-competition use” by the World Anti-Doping Agency. The majority of the research on phenylpiracetam has still yet to be translated into English and cannot be found easily online.
          Nevertheless, the racetam family (this class of drug) are some of the best-studied and the most recognized cognitive-enhancing compounds on earth.
          * They have been found to have very few side effects.

          Originating out of the research labs in Moscow 1983, phenylpiracetam was first used to serve Russian astronauts during long periods of work in space, primarily for the purpose of preventing stress and maintaining work efficiency.

          One of the most popularly cited effects of Racetams (2010) has recognized the compound for its potent effect as an anti-cognitive decline agent, in both elderly and younger subjects. The study tested dosages of 200-600mg/day for 30 days to find that it can produce the following effects;

          • anti-amnesic
          • antidepressant
          • anticonvulsant
          • anxiolytic
          • memory enhancement

          This is supported by another study (2005) finding that:

          “Patients exhibited higher mobility and daily activity, along with lower discomfort, anxiety and depression. EEG study showed more intensive alpha- and beta-rhythms…”

          All of this suggests that phenylpiracetam supplementation can act as a potent anti-depressant/anxiolytic drug that has additional improvements in cognition.

          However, as many report this supplement to promote wakefulness, it is not recommended to take Phenylpiracetam after midday or within 12 hours of sleep.

          This compound does not promote euphoria nor have any psychostimulatory effects. Even so, users are advised to supplement with caution.

          *If you decide to supplement within the Racetam class, it’s recommended that you additionally take an acetylcholine precursor. This includes Alpha GPC/CDP Choline.

           

          Nootropic For Anxiety #1 L-theanine 

          What is it?

          Theanine is a non-essential amino acid. That is the body can function perfectly fine without it. Natural sources of this include; green and black teas, white tea, C. japonica and C. sasanqua, and a mushroom called Xerocomus badius.

          What it does

          After crossing the blood-brain barrier, the amino acid works to up-regulate inhibitory neurotransmitters by blocking the binding of L-glutamic acid to glutamate receptors.

          L-theanine is also thought to modulate serotonin and dopamine levels in select areas of the brain.

          This creates a calming effect that kicks in about 30 to 40 minutes of consumption often lasting 8 to 10 hours.

          Dosage

          Dosages of 50 to 200 mg show marked improvements in anxiety symptoms. However, doses of 400mg per day are noted as “typically safe and well-tolerated”.

          What are the Benefits?

          Science has provided us with a great deal of promising research on this topic. Some of which include;

          •  Significantly decrease symptoms of anxiety, including increased heart rate, and increased secretion of immunoglobulin A. [study]
          • Increases alpha waves in the parietal and occipital regions of the brain. (This electrical activity is the same as those observed during meditation).
          • Doses of 250 mg and 400 mg of L-theanine greatly improved sleep in animals and humans [study].
          • Enhanced comfort for those diagnosed with schizophrenia [study].

          Safety

          EGCG found in green tea has been known to reduce the efficacy of some chemotherapy drugs and for that reason, is not recommended for cancer patients.

           

          Conclusion

          So there you have it. Your very own ultimate guide on Nootropics For Anxiety. It is clear that the progressive research behind this interesting topic is now becoming more valid, and implementing all the tips given today will likely help you break free of your anxiety woes sooner rather than later. At least they have for me. To which I remind all – it is essential to only use supplements in a “cyclic” fashion. This is true for all drugs, even caffeine.

           

           

           

           

           

          Grape Seed Extract Testosteone

          Grape Seed Extract | Testosterone

           

          If you’re like me, you’ve probably heard about the potential game-changing effects of Grape Seed Extract on Testosterone. One of the most crucial elements to working out harder & recovering better lies in your ability to raise and utilize testosterone. So, after a little research, I found some studies that investigate this Grape Seed Extract and what it may be able to do for low testosterone.

          Studies show that in certain populations compounds found within Grape Seed Extract can raise levels of free testosterone in the blood.  This is reportedly due to the compound known as procyanidin B2, which acts as an aromatase inhibitor. This inhibits the conversion of free testosterone into estrogen and estradiol in the body. However, there are still a few things that you need to consider before taking Grape Seed Extract for Testosterone. Let’s look at if this supplement is the right choice for you.

           

          What is Grape Seed Extract?

          Normally harvested for the fermentation & production of wine, the Grape has recently struck the interest of fitness fanatics who report that Grape Seed’s Extract can produce powerful testosterone boosting effects enabling users to burn more fat and grow more muscle easier & faster.

          Unsurprisingly, Grape Seed Extract is derived from the seeds of grapes. It is produced by grinding up the seeds found at the center of the grape and then, using steam distillation or cold pressing, the pure contents from within the grape are extracted.

           

          Benefits of Grape Seed Extract

          Compounds within the grape, particularly the seed, have long been recognized as a potent source of polyphenols and antioxidants which undeniably play key roles in the maintenance of the health of cells in our body.

          Anecdotally the compounds within Grape Seed Extract have been found to assist with:

          • Lowering cholesterol
          • Aiding weight loss
          • Increasing cognitive function
          • Regulation of blood pressure
          • Optimizing fluid balance
          • Speeding the healing of wounds
          • Reducing swelling after an injury
          • Preventing muscle damage

          Reports even show that Grape Seeds have been used for their wide range of health benefits over the last 10,000 years!

          But does Grape Seed Extract Boost Testosterone? How may it be beneficial to you and your training? And are there any risks of using this supplement? The good news is that scientists have also been interested in this topic and have conducted research on the various effects of the Grape (Vitis vinifera) seed extract. Here is what the science says. But first a few precautions.

           

          Who should NOT Take Grape Seed Extract?

          Although the NCCIH states that Grape Seed Extract is “generally well tolerated when consumed in moderate amounts”, before consuming Grape Seed Extract for Testosterone enhancement it is recommended that you consult your doctor.

          The following populations are strongly advised to avoid Grape Seed Extract consumption:

          • Those who are pregnant. The growing fetus requires ample amounts of estrogen to grow optimally, you do not want to risk your baby’s health over a little extra gain in the gym!
          • Those taking anticoagulant medications (aka blood thinner) e.g. Plavix, Aspirin, or Coumadin.
          • Those with liver impairments

          The interaction between Grape Seed Extract & other drugs is not well understood.

          Before taking it is advised that you consult your doctor.

           

          Can Grape Seed Extract boost testosterone?

          Alright, so now to the good stuff.

          Maybe you heard it from that shredded fitness YouTuber, or maybe it was your fitness fanatic friend who swore by the testosterone-boosting effects of Grape Seed Extract. And so now wanna try some. But you’re probably wondering “could this plant supplement really have an effect on my ability to recover and train more effectively?”.

          In short, research has produced some findings that support the concept of increased testosterone following Grape Seed Extract supplementation. However, there is more to this relationship than meets the eye. 

          Rather, instead of directly increasing Testosterone levels, the compounds found within Grape Seed Extract have been known to inhibit the production of estrogen and estradiol (the hormones in which act to counterbalance testosterone levels in the body). Or for you science lovers out there, Grape Seed Extract reportedly contains a substance called procyanidin B2, which is a naturally occurring aromatase inhibitor.

          Let me explain a little further.

          Excess testosterone circulating in the body will undergo a process known as aromatization. During which, the aromatase enzyme will chemically convert free testosterone to estrogen and estradiol. Ultimately, this enzyme’s job is to reduce the amount of available testosterone in the body and increase the amount of available estrogen and estradiol.

          So Grape Seed Extract Can Increase Testosterone?

          Well, not so fast.. One key factor is often forgotten when discussing this topic. That is, the conversion of free testosterone to estradiol and estrone in the body does not solely rely on the action of the aromatase enzyme and can occur via a host of different pathways.

          Despite this, [one study] that looked at the effects Letrozole, (another aromatase inhibiting drug), found that testosterone in both younger and older males can be seen to rise 146% after 28 days of consumption!

          What’s even more interesting, is that luteinizing hormone, which controls the production of testosterone, was also observed to be elevated by a whopping 339 and 323% in the young and the elderly, respectively.

          Theoretically, this means supplementation with Grape Seed Extract can potentially be beneficial in the elevation of testosterone, leading to increased performance and recovery.

           

          Should Women Avoid Supplementing with Grape Seed Extract?

          So, does this mean that if you’re a woman who is considering supplementing with Grape Seed Extract, you should be concerned about potentially raising your levels of male sex hormones?

          Not really. Because of the various mechanisms that the body can utilize to create and recycle both male and female sex hormones, the chance that you will develop male sex characteristics are slim. [One study] even suggests that females who have a genetic tendency for certain types of breast cancers can potentially fight tumor development after supplementation of aromatase inhibiting compounds.

           

          Although still, an area needed for further research, there is increasing evidence to suggest that these compounds are effective in treatments of some breast cancer growths.

          But it important to remember that the trials performed with such drugs have the potential to produce a host of negative side effects in some patients.

           

          Signs That You Need to Stop Taking Grape Seed Extract

          Whether using for testosterone or not, you should stop supplementing with Grape Seed Extract if you experience any of the following adverse effects:

          • Nausea/vomiting
          • Headache
          • Dizziness
          • Stomach/throat Pain
          • Itching scalp

           

          How Much Grape Seed Extract to Take for Testosterone Enhancement?

          Given that the only food source for this extract is grape seeds, the supplement form is the most logical form of ingestion.

          The recommended dosage for those looking to increase testosterone should start at around 100 milligrams per day, slowly increasing doses of up to 300 milligrams per day.

          While experimenting with how your body reacts to the supplement please stay aware of the aforementioned symptoms. It is important to keep a close eye on your reaction to this supplement.

          If you are pregnant or planning a pregnancy, we again remind you to avoid consumption.

           

          What Are the Best Ways to Increase Testosterone?

           

           

           

           

           

           

           

           

           

          More and more people are turning to the use of synthetic hormone replacements in the form of patches and creams to counteract the side effects of lower testosterone. However, along with the supplementation of Grape Seed Extract, there are many other natural behaviors and nutrients that are believed to have powerful testosterone increasing effects. And you can start benefiting from them today!

          Science reveals that the following natural approaches can similarly increase testosterone levels:

          • Lowering stress [study]
          • Supplementing with Vitamin D or enjoying more sun exposure [study]
          • Exercising larger muscle groups in the form of compound exercises & high-intensity interval training [study]
          • Supplementing with Ashwagandha [study]

           

          Why Is Testosterone Worth Worrying About?

          Due to our modern-day fast-paced lifestyles, it is becoming increasingly common for individuals to suffer the negative effects of low testosterone, some of which include:

          • Lower Libido
          • Muscle Atrophy and Impaired Recovery
          • Fatigue
          • Brain Fog
          • Depression
          • Increased Fat Storage

          This problem is becoming a cause of increasing concern as the link between low testosterone and premature death is growing ever stronger.

          Not only for men, but Testosterone is also essential for women as many of the female hormones like estrogen and progesterone rely on a balance with testosterone to work effectively.

          Therefore, if you suffer from any of the above symptoms you may benefit greatly by implementing the tips given today

           

          Conclusion

          So, while plausible that the consumption of Grape Seed Extract could potentially increase testosterone levels AND decrease the risks of some cancers, there is currently limited evidence to say confidently that these effects can be powerful enough to impact athletic performance & recovery. That being said, there have not been enough studies on the effects of Grape Seed Extract upon Testosterone.

          Nevertheless, research is becoming clear that the abundant nutrition profile high in vitamin E and antioxidants can provide many users with the sensation of:

          • Higher stamina
          • Increased Ability to Burn Fat & Build Muscle
          • Clearer Skin
          • Improving Cognitive Performance

          Could these anecdotal claims be due to the inhibition of female-hormone-producing enzymes or simply a factor of achieving more vitamins and antioxidants?

          Let us know what you think down in the comments below ⬇